Sex-structured model of Wolbachia invasion and design of sex-biased release strategies in Aedes spp mosquitoes populations

Bliman Pierre-Alexandre, Dumont Yves, Escobar-Lasso Oscar Eduardo, Martinez-Romero Hector J., Vasilieva Olga. 2023. Sex-structured model of Wolbachia invasion and design of sex-biased release strategies in Aedes spp mosquitoes populations. Applied Mathematical Modelling, 119 : 319-412.

Résumé : Laboratory experiments as well as some field essays have revealed that the intracellular bacterium Wolbachia, deliberately introduced in Aedes spp female mosquitoes, drastically reduces their vector competence for dengue virus and, also, other mosquito-borne viral diseases. However, female mosquitoes infected with Wolbachia still need to ingest human blood while male mosquitoes, either wild or Wolbachia-carrying, do not bite people. As such, Wolbachia-carrying females may transmit the virus to people during blood-feeding, even though with far less probability than the wild ones. Therefore, massive releases of Wolbachia-carrying females may increase both the nuisance and the epidemiological risk among human residents. With the goal of exploring in depth the practical aspects of sex-biased releases, we introduce in this paper a simple sex-structured model of Wolbachia invasion that brings forward the possibility of developing male-biased release strategies of Wolbachia-carriers leading to Wolbachia invasion. Thanks to this model, we study at length the minimal amount of mosquitoes necessary to complete this task, according to the relative sex-ratio of the released mosquitoes and the release schedule. We also pay attention to the estimate of the time needed to achieve the ultimate population replacement.

Mots-clés Agrovoc : Wolbachia, Aedes, vecteur de maladie, lutte anti-insecte, modèle de simulation, modélisation

Mots-clés libres : Wolbachia symbiont, Population replacement, Sex-structured model, Aedes, Male-biased release, Qualitative analysis, Ordinary differential equation, Numerical simulations

Classification Agris : L72 - Organismes nuisibles des animaux
L73 - Maladies des animaux
U10 - Informatique, mathématiques et statistiques

Champ stratégique Cirad : CTS 4 (2019-) - Santé des plantes, des animaux et des écosystèmes

Agences de financement hors UE : Fondo Nacional de Financiamiento Para la Ciencia, la Tecnología y la Innovación, Fondo José de Caldas

Auteurs et affiliations

• Bliman Pierre-Alexandre, Université Paris-Sorbonne (FRA) - auteur correspondant
• Dumont Yves, CIRAD-BIOS-UMR AMAP (REU) ORCID: 0000-0003-4817-685X
• Escobar-Lasso Oscar Eduardo, Universidad del Valle (COL)
• Martinez-Romero Hector J., Universidad del Valle (COL)
• Vasilieva Olga, Universidad del Valle (COL)

Source : Cirad-Agritrop (https://agritrop.cirad.fr/604148/)

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