Frutos Roger, Serra-Cobo Jordi, Chen Tianmu, Devaux Christian A.. 2020. COVID-19: Time to exonerate the pangolin from the transmission of SARS-CoV-2 to humans. Infection, Genetics and Evolution, 84:104493, 5 p.
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Quartile : Q3, Sujet : INFECTIOUS DISEASES
Liste HCERES des revues (en SHS) : oui
Thème(s) HCERES des revues (en SHS) : Anthropologie-Ethnologie
Résumé : The emergence of COVID-19 has triggered many works aiming at identifying the animal intermediate potentially involved in the transmission of SARS-CoV-2 to humans. The presence of SARS-CoV-2-related viruses in Malayan pangolins, in silico analysis of the ACE2 receptor polymorphism and sequence similarities between the Receptor Binding Domain (RBD) of the spike proteins of pangolin and human Sarbecoviruses led to the proposal of pangolin as intermediary. However, the binding affinity of the pangolin ACE2 receptor for SARS-CoV-2 RBD was later on reported to be low. Here, we provide evidence that the pangolin is not the intermediate animal at the origin of the human pandemic. Moreover, data available do not fit with the spillover model currently proposed for zoonotic emergence which is thus unlikely to account for this outbreak. We propose a different model to explain how SARS-CoV-2 related coronaviruses could have circulated in different species, including humans, before the emergence of COVID-19.
Mots-clés Agrovoc : covid-19, coronavirus 2 du syndrome respiratoire aigu sévère, genre humain, Pholidota, animal, transmission des maladies
Mots-clés libres : COVID-19, SARS-COV-2, Coronavirus, Pangolin, Zoonosis, Zoonotic model
Agences de financement hors UE : Université de Marseille, Centre National de la Recherche Scientifique, Centre de Coopération Internationale en Recherche Agronomique pour le Développement, Universitat de Barcelona, Xiamen University, Bill and Melinda Gates Foundation
Auteurs et affiliations
- Frutos Roger, CIRAD-BIOS-UMR INTERTRYP (FRA) - auteur correspondant
- Serra-Cobo Jordi, Universitat de Barcelona (ESP)
- Chen Tianmu, Xiamen University (CHN)
- Devaux Christian A., CNRS (FRA)
Source : Cirad-Agritrop (https://agritrop.cirad.fr/605392/)
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