Molecular epidemiology of contagious Caprine pleuropneumonia

Manso-Silvan Lucia. 2023. Molecular epidemiology of contagious Caprine pleuropneumonia. . Faculty of Veterinary Sciences and Animal Husbandry. Shuhama : Faculty of Veterinary Sciences and Animal Husbandry, Résumé, 1 p. Mycoplasmosis Workshop: diagnosis and vaccines for goats, with special focus on CCPP, Shuhama, Inde, 7 Novembre 2023/7 Novembre 2023.

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Résumé : Contagious caprine pleuropneumonia (CCPP), caused by Mycoplasma capricolum subsp. capripneumoniae (Mccp), is a devastating disease of domestic goats and of some wild ungulate species. The disease is currently spreading in Africa and Asia and poses a serious threat to disease-free areas. A comprehensive view of the evolutionary history and dynamics of Mccp is essential to understand the epidemiology of CCPP. Yet, analysing the diversity of genetically monomorphic pathogens, such as Mccp, is complicated due to their low variability. We have investigated the molecular epidemiology of CCPP using both Multi-Locus Sequence Analysis (MLSA) and whole genome approaches. Combining large-scale genomic data with spatial and temporal data made it possible to obtain a comprehensive view of the epidemiology and evolutionary history of CCPP for the development of improved disease surveillance and control measures. On the other hand, recent multi-locus sequence analysis of Mccp strains from Asia revealed unforeseen diversity and a central position for genotyping groups representing strains from Central/East Asia, suggesting a possible origin of contagious caprine pleuropneumonia in this continent. A better assessment of the emergence, diversity and distribution of Mccp in Asia and Africa calls for renewed efforts to dramatically enlarge the sample of strains. Availability and affordability in the field, added to superior typeability (directly from poor samples) and high stability, discriminatory power and concordance with epidemiological and phylogenetic analyses, make MLSA an excellent tool for such investigations.

Mots-clés libres : Contagious caprine pleuropneumonia (CCPP), Mycoplasma capricolum subsp. capripneumoniae (Mccp), Molecular epidemiology

Auteurs et affiliations

• Manso-Silvan Lucia, CIRAD-BIOS-UMR ASTRE (FRA) ORCID: 0000-0002-5539-3804

Source : Cirad-Agritrop (https://agritrop.cirad.fr/608389/)

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