Extensive survey and analysis of factors associated with presence of antibodies to orthoebolaviruses in bats from West and Central Africa

Peeters Martine, Champagne Maëliss, Ndong Bass Innocent, Goumou Souana, Ndimbo Kumugo Simon-Pierre, Lacroix Audrey, Esteban Amandine, Meta Djomsi Dowbiss, Soumah Abdoul Karim, Mbala Kingebeni Placide, Mba Djonzo Flaubert Auguste, Lempu Guy, Thaurignac Guillaume, Mpoudi Ngole Eitel, Kouanfack Charles, Mukadi Bamuleka Daniel, Likofata Jacques, Muyembe Tamfum Jean-Jacques, De Nys Hélène, Capelle Julien, Toure Abdoulaye, Delaporte Eric, Keita Alpha Kabinet, Ahuka Mundeke Steve, Ayouba Ahidjo. 2023. Extensive survey and analysis of factors associated with presence of antibodies to orthoebolaviruses in bats from West and Central Africa. Viruses, 15 (9):1927, 20 p.

https://doi.org/10.3390/v15091927

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Url - jeu de données - Entrepôt autre : https://rr-africa.woah.org/en/projects/ebo-sursy-en/

Résumé : The seroprevalence to orthoebolaviruses was studied in 9594 bats (5972 frugivorous and 3622 insectivorous) from Cameroon, the Democratic Republic of Congo (DRC) and Guinea, with a Luminex-based serological assay including recombinant antigens of four orthoebolavirus species. Seroprevalence is expressed as a range according to different cut-off calculations. Between 6.1% and 18.9% bat samples reacted with at least one orthoebolavirus antigen; the highest reactivity was seen with Glycoprotein (GP) antigens. Seroprevalence varied per species and was higher in frugivorous than insectivorous bats; 9.1–27.5% versus 1.3–4.6%, respectively. Seroprevalence in male (13.5%) and female (14.4%) bats was only slightly different and was higher in adults (14.9%) versus juveniles (9.4%) (p < 0.001). Moreover, seroprevalence was highest in subadults (45.4%) when compared to mature adults (19.2%), (p < 0.001). Our data suggest orthoebolavirus circulation is highest in young bats. More long-term studies are needed to identify birthing pulses for the different bat species in diverse geographic regions and to increase the chances of detecting viral RNA in order to document the genetic diversity of filoviruses in bats and their pathogenic potential for humans. Frugivorous bats seem more likely to be reservoirs of orthoebolaviruses, but the role of insectivorous bats has also to be further examined.

Mots-clés Agrovoc : Chiroptera, sérologie, surveillance épidémiologique, Ebolavirus, variation génétique, anticorps, maladie à virus Ébola, santé publique

Mots-clés géographiques Agrovoc : Cameroun, République démocratique du Congo, Guinée

Mots-clés libres : Ebola, Africa, Bats, Virus, Antibody

Classification Agris : L73 - Maladies des animaux

Champ stratégique Cirad : CTS 4 (2019-) - Santé des plantes, des animaux et des écosystèmes

Agences de financement européennes : European Commission

Agences de financement hors UE : Institut National de la Santé et de la Recherche Médicale, Agence Nationale de la Recherche

Projets sur financement : (EU) EBO-SURSY project, (FRA) Biodiversity changes in African forests and Emerging Infectious Diseases: should we worry?

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