Temperature dependence of the mutation rate towards antibiotic resistance

Van Eldijk Timo J.B., Sheridan Eleanor A., Martin Guillaume, Weissing Franz J., Kuipers Oscar P., Van Doorn G. Sander. 2024. Temperature dependence of the mutation rate towards antibiotic resistance. JAC-Antimicrobial Resistance, 6 (3), 5 p.

Url - jeu de données - Entrepôt autre : https://doi.org/10.34894/BG4ZS8

Résumé : Objectives: Environmental conditions can influence mutation rates in bacteria. Fever is a common response to infection that alters the growth conditions of infecting bacteria. Here we examine how a temperature change, such as is associated with fever, affects the mutation rate towards antibiotic resistance. Methods: We used a fluctuation test to assess the mutation rate towards antibiotic resistance in Escherichia coli at two different temperatures: 37°C (normal temperature) and 40°C (fever temperature). We performed this measurement for three different antibiotics with different modes of action: ciprofloxacin, rifampicin and ampicillin. Results: In all cases, the mutation rate towards antibiotic resistance turned out to be temperature dependent, but in different ways. Fever temperatures led to a reduced mutation rate towards ampicillin resistance and an elevated mutation rate towards ciprofloxacin and rifampicin resistance. Conclusions: This study shows that the mutation rate towards antibiotic resistance is impacted by a small change in temperature, such as associated with fever. This opens a new avenue to mitigate the emergence of antibiotic resistance by coordinating the choice of an antibiotic with the decision of whether or not to suppress fever when treating a patient. Hence, optimized combinations of antibiotics and fever suppression strategies may be a new weapon in the battle against antibiotic resistance.

Mots-clés Agrovoc : Résistance aux antibiotiques, mutation, antibiotique, température, Escherichia coli, facteur du milieu

Mots-clés géographiques Agrovoc : France

Agences de financement européennes : European Commission

Auteurs et affiliations

• Van Eldijk Timo J.B., University of Groningen (NLD) - auteur correspondant
• Sheridan Eleanor A., University of Groningen (NLD)
• Martin Guillaume, CIRAD-BIOS-UMR AGAP (FRA) ORCID: 0000-0002-1801-7500
• Weissing Franz J., University of Groningen (NLD)
• Kuipers Oscar P., University of Groningen (NLD)
• Van Doorn G. Sander, University of Groningen (NLD)

Source : Cirad-Agritrop (https://agritrop.cirad.fr/612922/)

Métriques

[ Page générée et mise en cache le 2025-09-23 ]