Contaminant hepatotoxins as culprits for kava hepatotoxicity - fact or fiction?

Teschke Rolf, Sarris Jérôme, Lebot Vincent. 2013. Contaminant hepatotoxins as culprits for kava hepatotoxicity - fact or fiction?. Phytotherapy Research, 27 (3) : 472-474.

Quartile : Q2, Sujet : PHARMACOLOGY & PHARMACY / Quartile : Q2, Sujet : CHEMISTRY, MEDICINAL

Liste HCERES des revues (en SHS) : oui

Thème(s) HCERES des revues (en SHS) : Psychologie-éthologie-ergonomie

Résumé : The culprit of kava hepatotoxicity will continue to remain a mystery in humans, if the underlying reaction is of idiosyncratic, unpredictable, and dose-independent nature due potentially to some metabolic aberration in a few individuals emerging from kava use. In addition, kava hepatotoxicity is presently not reproducible experimentally in preclinical models, as demonstrated by studies showing whole kava extracts are not hepatotoxic. This led us to propose our 'working hypothesis' that contaminant hepatotoxins including moulds might have caused rare kava hepatotoxicity in humans. Further studies are now warranted to proof or disproof our working hypothesis, because kava hepatotoxicity possibly based on contaminant hepatotoxins could be a preventable disease. In the meantime, however, for minimizing toxicity risk in kava users, a pragmatic approach should focus on the medicinal use of an aqueous extract derived from peeled rhizomes and roots of a non-mouldy noble kava cultivar, limited to maximum 250-mg kavalactones daily for acute or intermittent use.

Classification Agris : Q03 - Contamination et toxicologie alimentaires
F60 - Physiologie et biochimie végétale

Champ stratégique Cirad : Axe 3 (2005-2013) - Alimentation accessible et de qualité

Auteurs et affiliations

• Teschke Rolf, University of Frankfurt (DEU)
• Sarris Jérôme, University of Melbourne (AUS)
• Lebot Vincent, CIRAD-BIOS-UMR AGAP (VUT)

Source : Cirad - Agritrop (https://agritrop.cirad.fr/568283/)

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