Testing a new formulation for Peste des Petits Ruminants vaccine in Ethiopia

Silva Ana Carina, Yami Martha, Libeau Geneviève, Carrondo Manuel J.T., Alves Paula M.. 2014. Testing a new formulation for Peste des Petits Ruminants vaccine in Ethiopia. Vaccine, 32 (24) : 2878-2881.

Quartile : Q2, Sujet : MEDICINE, RESEARCH & EXPERIMENTAL / Quartile : Q2, Sujet : IMMUNOLOGY

Résumé : In this paper extended tests on a new candidate formulation for Peste des Petits Ruminants (PPR) vaccine carried out at National Veterinary Institute (NVI) in Ethiopia are presented. This work was performed in the frame of the VACNADA project from GALVmed which aimed at procuring vaccines against neglected veterinary diseases to African vaccine producing laboratories, in particular PPR. After the eradication of Rinderpest, Peste des Petits Ruminants became the next veterinary disease on target for elimination, requiring an effective and thermostable vaccine. In this work a Tris/Trehalose formulation was evaluated in thermal stability studies in comparison to the current used formulation of the live attenuated PPR vaccine, the Weybridge medium. The extended results presented herein show an increased thermal stability of the vaccine, especially at 37 and 45 °C, as expected from previously published results (Silva A.C. et al., 2011). Furthermore, during the course of this project, the NVI teams have clearly demonstrated ability to produce higher quality PPR vaccines after a successful transfer of the technology. These results should significantly enhance the utility of the vaccine in the eradication of PPR.

Mots-clés Agrovoc : peste des petits ruminants, vaccin, virus peste petits ruminants, aptitude à la conservation, stabilité, température, chaîne du froid, qualité, contrôle de maladies, transfert de technologie

Mots-clés géographiques Agrovoc : Éthiopie

Classification Agris : L73 - Maladies des animaux

Champ stratégique Cirad : Axe 4 (2014-2018) - Santé des animaux et des plantes

Auteurs et affiliations

• Silva Ana Carina, IBET (PRT)
• Yami Martha, NVI (ETH)
• Libeau Geneviève, CIRAD-BIOS-UMR CMAEE (FRA)
• Carrondo Manuel J.T., IBET (PRT)
• Alves Paula M., IBET (PRT)

Source : Cirad - Agritrop (https://agritrop.cirad.fr/573300/)

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