Preventive nutritional supplementation with furan fatty acid in a DIO mouse model increases muscle mass and reduces metabolic disorders

Dore Laetitia, Durand Erwann, Bonafos Béatrice, Chaiyut Jatuporn, Vaysse Laurent, Liengprayoon Siriluck, Gaillet Sylvie, Pessemesse Laurence, Lambert Karen, Bertrand-Gaday Christelle, Coudray Charles, Sultan Ariane, Casas François, Feillet-Coudray Christine. 2023. Preventive nutritional supplementation with furan fatty acid in a DIO mouse model increases muscle mass and reduces metabolic disorders. Biomedicine and Pharmacotherapy, 164:114945

Résumé : The increase in obesity has become a major global health problem and is associated with numerous metabolic dysfunctions. Furan fatty acids (FuFAs) are minor lipids present in our diet. Recently we showed that FuFA-F2 extracted from Hevea brasiliensis latex stimulates muscle anabolism in mice in vitro and in vivo, mimicking in part physical activity. While skeletal muscle is essential for energy metabolism and is the predominant site of insulin-mediated glucose uptake in the post prandial state, our results suggested that FuFA-F2 could have favorable effects against obesity. The aim of this work was therefore to study whether a preventive nutritional supplementation with FuFA-F2 (40 mg or 110 mg/day/kg of body weight) in a diet-induced obesity (DIO) mouse model may have beneficial effects against obesity and liver and skeletal muscle metabolic dysfunction. We showed that 12 weeks of FuFA-F2 supplementation in DIO mice decreased fat mass, increased lean mass and restored normal energy expenditure. In addition, we found that FuFA-F2 improved insulin sensitivity. We revealed that FuFA-F2 increased muscle mass but had no effect on mitochondrial function and oxidative stress in skeletal muscle. Furthermore, we observed that FuFA-F2 supplementation reduced liver steatosis without impact on mitochondrial function and oxidative stress in liver. Our findings demonstrated for the first time that a preventive nutritional supplementation with a furan fatty acid in DIO mice reduced metabolic disorders and was able to mimic partly the positive effects of physical activity. This study highlights that nutritional FuFA-F2 supplementation could be an effective approach to treat obesity and metabolic syndrome.

Mots-clés Agrovoc : Hevea brasiliensis, acide gras, métabolisme, latex, trouble nutritionnel, trouble du métabolisme, muscle, stress oxydatif, régime alimentaire, obésité, insuline, dépense énergétique, souris, furane

Mots-clés géographiques Agrovoc : Thaïlande

Mots-clés libres : Furan fatty acids, Obesity, Insulin sensitivity, Skeletal muscle, Liver, Mitochondria

Classification Agris : L50 - Physiologie et biochimie animales
L02 - Alimentation animale
L70 - Sciences et hygiène vétérinaires - Considérations générales

Champ stratégique Cirad : CTS 4 (2019-) - Santé des plantes, des animaux et des écosystèmes

Agences de financement hors UE : Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement, Groupe Lipides et Nutrition, Montpellier Université d'Excellence

Auteurs et affiliations

• Dore Laetitia, Université de Montpellier (FRA)
• Durand Erwann, CIRAD-PERSYST-UMR Qualisud (FRA) ORCID: 0000-0002-0306-8081
• Bonafos Béatrice, INRAE (FRA)
• Chaiyut Jatuporn, Kasetsart University (THA)
• Vaysse Laurent, CIRAD-PERSYST-UPR BioWooEB (FRA)
• Liengprayoon Siriluck, Kasetsart University (THA)
• Gaillet Sylvie, UM2 (FRA)
• Pessemesse Laurence, INRAE (FRA)
• Lambert Karen, INSERM (FRA)
• Bertrand-Gaday Christelle, INRAE (FRA)
• Coudray Charles, INRAE (FRA)
• Sultan Ariane, Université de Montpellier (FRA)
• Casas François, INRAE (FRA) - auteur correspondant
• Feillet-Coudray Christine, INRAE (FRA) - auteur correspondant

Source : Cirad-Agritrop (https://agritrop.cirad.fr/604792/)

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