Microbe Profile: Ehrlichia ruminantium - stealthy as it goes

Meyer Damien, Moumène Amal, Rodrigues Valérie. 2023. Microbe Profile: Ehrlichia ruminantium - stealthy as it goes. Microbiology, 169 (11), 4 p.

Résumé : Ehrlichia ruminantium is an obligate intracellular pathogenic bacterium that causes heartwater, a fatal disease of ruminants in tropical areas. Some human cases have also been reported. This globally important pathogen is primarily transmitted by ticks of the Amblyomma genus and threatens American mainland. E. ruminantium replicates within eukaryotic mammal or tick cell is a membrane-bound vacuole, where it undergoes a biphasic developmental growth cycle and differentiates from noninfectious replicative form into infectious elementary bodies. The ability of E. ruminantium to hijack host cellular processes and avoid innate immunity is a fundamental, but not yet fully understood, virulence trait of this stealth pathogen in the genomic era.

Mots-clés Agrovoc : Ehrlichia ruminantium, Ehrlichia, Rickettsiales, maladie bactérienne, Amblyomma variegatum, pathogénèse, pouvoir pathogène, Amblyomma hebraeum, virulence, ovin, maladie transmissible par tiques, agent pathogène, effecteur moléculaire

Mots-clés géographiques Agrovoc : France, Guadeloupe

Mots-clés libres : Effectors, Ehrlichia, Intracellular bacteria, Outer membrane protein, Pathogenesis, Type IV secretion system

Classification Agris : L73 - Maladies des animaux

Champ stratégique Cirad : CTS 4 (2019-) - Santé des plantes, des animaux et des écosystèmes

Auteurs et affiliations

• Meyer Damien, CIRAD-BIOS-UMR ASTRE (GLP) ORCID: 0000-0003-2735-176X - auteur correspondant
• Moumène Amal, Université de Montpellier (FRA)
• Rodrigues Valérie, CIRAD-BIOS-UMR ASTRE (GLP)

Source : Cirad-Agritrop (https://agritrop.cirad.fr/607354/)

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