Overloading the immunity of the mosquito Anopheles gambiae with multiple immune challenges

Barreaux Antoine, Barreaux Priscille, Koella Jacob C.. 2016. Overloading the immunity of the mosquito Anopheles gambiae with multiple immune challenges. Parasites and Vectors, 9:210, 4 p.

Url - jeu de données - Entrepôt autre : https://figshare.com/articles/journal_contribution/Additional_file_1_of_Overloading_the_immunity_of_the_mosquito_Anopheles_gambiae_with_multiple_immune_challenges/4425734

Quartile : Q1, Sujet : PARASITOLOGY

Résumé : Background: Melanisation – the production and deposition of a layer of melanin that encapsulates many pathogens, including bacteria, filarial nematodes and malaria parasites is one of the main immune responses in mosquitoes. Can a high parasite load overload this immune response? If so, how is the melanisation response distributed among the individual parasites? Methods: We considered these questions with the mosquito Anopheles gambiae by inoculating individuals simultaneously with one, two or three negatively charged Sephadex beads, and estimating the melanisation as the darkness of the bead (which ranges from about 0 for unmelanised beads to 100 for the most melanised beads of our experiment). Results: As the number of beads increased, the average degree to which beads were melanised decreased from 71 to 50. While the darkness of the least melanised bead in a mosquito decreased from an average of 71 to 35, the darkness of the most strongly melanised one did not change with the number of beads. Conclusions: As the number of beads increased, the mosquito's immune response became overloaded. The mosquito's response was to prioritise the melanisation of one bead rather than distributing its response over all beads. Such immune overloading may be an important factor underlying the evolution of resistance against vector-borne diseases.

Mots-clés Agrovoc : Anopheles gambiae, transmission des maladies, encapsulation, malaria, réponse immunitaire, immunité, mélanine

Mots-clés libres : Mosquito, Insect immunity, Melanisation, Anopheles gambiae, Immune overloading

Auteurs et affiliations

• Barreaux Antoine, Université de Neuchâtel (CHE) ORCID: 0000-0001-5822-761X - auteur correspondant
• Barreaux Priscille, Université de Neuchâtel (CHE)
• Koella Jacob C., Université de Neuchâtel (CHE)

Source : Cirad-Agritrop (https://agritrop.cirad.fr/609716/)

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