Daily consumption of golden berry (Physalis peruviana) has been shown to halt the progression of insulin resistance and obesity in obese rats with metabolic syndrome

Ángel-Martín Alberto, Vaillant Alexandre, Moreno-Castellanos Natalia. 2024. Daily consumption of golden berry (Physalis peruviana) has been shown to halt the progression of insulin resistance and obesity in obese rats with metabolic syndrome. Nutrients, 16 (3), n.spéc. Diet Composition, Eating Habits and Their Impact on Metabolic Diseases:365, 21 p.

Résumé : In a study addressing the high risk of chronic diseases in people with diabetes and obesity linked to metabolic syndrome, the impact of a Golden Berry diet was investigated using a diabetic animal model. Obese rats with diabetic characteristics were fed a diet containing five percent Golden Berry for 16 days. This study focused on various parameters including organ weights, expression of metabolic genes, and urinary biomarkers. Post-Golden Berry intake, there was a notable decrease in the body, liver, pancreas, visceral, and subcutaneous adipose tissue weights in these obese, hyperglycemic rats. In contrast, an increase in brown adipose tissue (BAT) cell mass was observed. This diet also resulted in reduced blood glucose levels and normalized plasma biochemical profiles, including cholesterol, triglycerides, LDL, and HDL levels. Additionally, it modulated specific urinary biomarkers, particularly pipe-colic acid, a primary marker for type 2 diabetes. Bioinformatics analysis linked these dietary effects to improved insulin signaling and adipogenesis. Regular consumption of Golden Berry effectively prevented insulin resistance and obesity in rats, underscoring its significant health benefits and the protective role of an antioxidant-rich diet against metabolic syndrome. These findings offer promising insights for future therapeutic strategies to manage and prevent obesity and related chronic diseases.

Mots-clés Agrovoc : Physalis, métabolisme, insuline, trouble du métabolisme, Physalis peruviana, tissu adipeux, régime alimentaire, contamination biologique, graisse brune, rat

Mots-clés libres : Golden Berry (Physalis peruviana), Metabolic syndrome, Insulin resistance, Obesity, Nutritional intervention

Agences de financement hors UE : Universidad Industrial de Santander

Auteurs et affiliations

• Ángel-Martín Alberto, Universidad Industrial de Santander (COL)
• Vaillant Alexandre, CIRAD-BIOS-UMR AGAP (FRA) ORCID: 0000-0002-4785-1350
• Moreno-Castellanos Natalia, Universidad Industrial de Santander (COL) - auteur correspondant

Source : Cirad-Agritrop (https://agritrop.cirad.fr/612967/)

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