Orientia tsutsugamushi, agent of scrub typhus, displays a single metapopulation with maintenance of ancestral haplotypes throughout continental South East Asia

Wongprompitak Patimaporn, Duong Veasna, Anukool Wichittra, Sreyrath Lay, Mai Trinh Thi Xuan, Gavotte Laurent, Moulia Catherine, Cornillot Emmanuel, Ekpo Pattama, Suputtamongkol Yupin, Buchy Philippe, Frutos Roger. 2015. Orientia tsutsugamushi, agent of scrub typhus, displays a single metapopulation with maintenance of ancestral haplotypes throughout continental South East Asia. Infection, Genetics and Evolution, 31 : 1-8.

https://doi.org/10.1016/j.meegid.2015.01.005

Article de revue ; Article de recherche ; Article de revue à facteur d'impact

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Quartile : Q2, Sujet : INFECTIOUS DISEASES

Liste HCERES des revues (en SHS) : oui

Thème(s) HCERES des revues (en SHS) : Anthropologie-Ethnologie

Résumé : Orientia tsutsugamushi is the causative agent of scrub typhus, a major cause of febrile illness in rural area of Asia–Pacific region. A multi-locus sequence typing (MLST) analysis was performed on strains isolated from human patients from 3 countries in Southeast Asia: Cambodia, Vietnam and Thailand. The phylogeny of the 56-kDa protein encoding gene was analyzed on the same strains and showed a structured topology with genetically distinct clusters. MLST analysis did not lead to the same conclusion. DNA polymorphism and phylogeny of individual gene loci indicated a significant level of recombination and genetic diversity whereas the ST distribution indicated the presence of isolated patches. No correlation was found with the geographic origin. This work suggests that weak divergence in core genome and ancestral haplotypes are maintained by permanent recombination in mites while the 56-kDa protein gene is diverging in higher speed due to selection by the mammalian immune system.

Mots-clés Agrovoc : rickettsiose, fièvre, Acaridae, Leptotrombidium, virus, génome

Mots-clés géographiques Agrovoc : Asie du Sud-Est, Cambodge, Viet Nam, Thaïlande

Mots-clés complémentaires : Orientia tsutsugamushi, Typhus des broussailles, Fièvre fluviale du Japon

Classification Agris : L73 - Maladies des animaux
S50 - Santé humaine

Champ stratégique Cirad : Axe 4 (2014-2018) - Santé des animaux et des plantes

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