Tick-borne diseases in cattle: Applications of proteomics to develop new generation vaccines

Marcelino Isabel, De Almeida André Martinho, Ventosa Miguel, Pruneau Ludovic, Meyer Damien, Martinez Dominique, Lefrançois Thierry, Vachiery Nathalie, Coelho Ana Varela. 2012. Tick-borne diseases in cattle: Applications of proteomics to develop new generation vaccines. Journal of Proteomics, 75 (14) : 4232-4250.

https://doi.org/10.1016/j.jprot.2012.03.026

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Quartile : Q1, Sujet : BIOCHEMICAL RESEARCH METHODS

Résumé : Tick-borne diseases (TBDs) affect 80% of the world's cattle population, hampering livestock production throughout the world. Livestock industry is important to rural populations not only as food supply, but also as a source of income. Tick control is usually achieved by using acaricides which are expensive, deleterious to the environment and can induce chemical resistance of vectors; the development of more effective and sustainable control methods is therefore required. Theileriosis, babesiosis, anaplasmosis and heartwater are the most important TBDs in cattle. Immunization strategies are currently available but with variable efficacy. To develop a new generation of vaccines which are more efficient, cheaper and safer, it is first necessary to better understand the mechanisms by which these parasites are transmitted, multiply and cause disease; this becomes especially difficult due to their complex life cycles, in vitro culture conditions and the lack of genetic tools to manipulate them. Proteomics and other complementary post-genomic tools such as transcriptomics and metabolomics in a systems biology context are becoming key tools to increase knowledge on the biology of infectious diseases. Herein, we present an overview of the so called "Omics" studies currently available on these tick-borne pathogens, giving emphasis to proteomics and how it may help to discover new vaccine candidates to control TBDs.

Mots-clés Agrovoc : bovin, vaccin, génie génétique, agent pathogène, vecteur de maladie, transmission des maladies, Ehrlichia, Theileria annulata, Theileria parva, Babesia bovis, Babesia bigemina, Anaplasma marginale, Metastigmata, Ehrlichia ruminantium