Frequent emergence and limited geographic dispersal of methicillin-resistant Staphylococcus aureus

Nübel Ulrich, Roumagnac Philippe, Feldkamp Mirjam, Song Jae-Hoon, Ko kwan soo, Huang Yhu-Chering, Coombs Geoffrey, Ip Margaret, Westh Henrik, Skov Robert, Struelens Marc J., Goering Richard V., Strommenger Birgit, Weller Annette, Witte Wolfgang, Achtman Mark. 2008. Frequent emergence and limited geographic dispersal of methicillin-resistant Staphylococcus aureus. Proceedings of the National Academy of Sciences of the United States of America, 105 (37) : 14130-14135.

Url - éditeur : http://www.jstor.org/stable/25464187

Liste HCERES des revues (en SHS) : oui

Thème(s) HCERES des revues (en SHS) : Economie-gestion; Psychologie-éthologie-ergonomie

Résumé : A small number of clonal lineages dominates the global population structure of methicillin-resistant Staphylococcus aureus (MRSA), resulting in the concept that MRSA has emerged on a few occasions after penicillinase-stable _-lactam antibiotics were introduced to clinical practice, followed by intercontinental spread of individual clones. We investigated the evolutionary history of an MRSA clone (ST5) by mutation discovery at 108 loci (46 kb) within a global collection of 135 isolates. The SNPs that were ascertained define a radial phylogenetic structure within ST5 consisting of at least 5 chains of mutational steps that define geographically associated clades. These clades are not concordant with previously described groupings based on staphylococcal protein A gene (spa) typing. By mapping the number of independent imports of the staphylococcal cassette chromosome methicillin-resistance island, we also show that import has occurred on at least 23 occasions within this single sequence type and that the progeny of such recombinant strains usually are distributed locally rather than globally. These results provide strong evidence that geographical spread of MRSA over long distances and across cultural borders is a rare event compared with the frequency with which the staphylococcal cassette chromosome island has been imported.

Mots-clés Agrovoc : Staphylococcus aureus, Résistance aux antibiotiques, phylogénie, évolution, variation génétique, dynamique des populations, distribution géographique, polymorphisme génétique, mutation, maladie de l'homme, épidémiologie

Mots-clés géographiques Agrovoc : Europe, Asie, Amérique du Nord, Australie, Amérique du Sud

Classification Agris : S50 - Santé humaine

Champ stratégique Cirad : Axe 4 (2005-2013) - Santé animale et maladies émergentes

Auteurs et affiliations

• Nübel Ulrich, Robert Koch-Institute (DEU)
• Roumagnac Philippe, Max-Planck Institut für Infektionsbiologie (DEU) ORCID: 0000-0001-5002-6039
• Feldkamp Mirjam, Max-Planck Institut für Infektionsbiologie (DEU)
• Song Jae-Hoon
• Ko kwan soo, Sungkyunkwan University (KOR)
• Huang Yhu-Chering
• Coombs Geoffrey
• Ip Margaret
• Westh Henrik
• Skov Robert
• Struelens Marc J., ULB (BEL)
• Goering Richard V.
• Strommenger Birgit, Robert Koch-Institute (DEU)
• Weller Annette, Robert Koch-Institute (DEU)
• Witte Wolfgang, Robert Koch-Institute (DEU)
• Achtman Mark, UCC (IRL)

Source : Cirad-Agritrop (https://agritrop.cirad.fr/577146/)

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