Major histocompatibility complex selection dynamics in pathogen-infected túngara frog (Physalaemus pustulosus) populations

Kosch Tiffany A., Bataille Arnaud, Didinger Chelsea, Eimes John A., Rodríguez-Brenes Sofia, Ryan Michael G., Waldman Bruce. 2016. Major histocompatibility complex selection dynamics in pathogen-infected túngara frog (Physalaemus pustulosus) populations. Biology Letters, 12 (8):e20160345, 6 p.

Url - jeu de données - Entrepôt autre : https://www.ncbi.nlm.nih.gov/nuccore/kr083833 / Url - jeu de données - Entrepôt autre : https://www.ncbi.nlm.nih.gov/nuccore/KT438737 / Url - jeu de données - Entrepôt autre : https://www.ncbi.nlm.nih.gov/nuccore/KT438741 / Url - jeu de données - Entrepôt autre : https://doi.org/10.5061/dryad.cn90m

Quartile : Q1, Sujet : BIOLOGY / Quartile : Q2, Sujet : ECOLOGY / Quartile : Q2, Sujet : EVOLUTIONARY BIOLOGY

Résumé : Pathogen-driven selection can favour major histocompatibility complex (MHC) alleles that confer immunological resistance to specific diseases. However, strong directional selection should deplete genetic variation necessary for robust immune function in the absence of balancing selection or challenges presented by other pathogens. We examined selection dynamics at one MHC class II (MHC-II) locus across Panamanian populations of the túngara frog, Physalaemus pustulosus, infected by the amphibian chytrid fungus Batrachochytrium dendrobatidis (Bd). We compared MHC-II diversity in highland túngara frog populations, where amphibian communities have experienced declines owing to Bd, with those in the lowland region that have shown no evidence of decline. Highland region frogs had MHC variants that confer resistance to Bd. Variant fixation appeared to occur by directional selection rather than inbreeding, as overall genetic variation persisted in populations. In Bd-infected lowland sites, however, selective advantage may accrue to individuals with only one Bd-resistance allele, which were more frequent. Environmental conditions in lowlands should be less favourable for Bd infection, which may reduce selection for specific Bd resistance in hosts. Our results suggest that MHC selection dynamics fluctuate in túngara frog populations as a function of the favourability of habitat to pathogen spread and the vulnerability of hosts to infection.

Mots-clés Agrovoc : résistance aux maladies, système mhc, dynamique des populations, immunologie, variation génétique, génétique des populations, Grenouille, sélection, agent pathogène

Classification Agris : L73 - Maladies des animaux
L50 - Physiologie et biochimie animales

Champ stratégique Cirad : Hors axes (2014-2018)

Auteurs et affiliations

• Kosch Tiffany A., Seoul National University (KOR)
• Bataille Arnaud, CIRAD-BIOS-UMR CMAEE (FRA) ORCID: 0000-0002-3508-2144
• Didinger Chelsea, Seoul National University (KOR)
• Eimes John A., Seoul National University (KOR)
• Rodríguez-Brenes Sofia, University of Texas (USA)
• Ryan Michael G., USDA (USA)
• Waldman Bruce, Seoul National University (KOR)

Source : Cirad-Agritrop (https://agritrop.cirad.fr/583218/)

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