Liver microbiome of Peromyscus leucopus, a key reservoir host species for emerging infectious diseases in North America

André A., Mouton Alice, Millien Virginie, Michaux Johan. 2017. Liver microbiome of Peromyscus leucopus, a key reservoir host species for emerging infectious diseases in North America. Infection, Genetics and Evolution, 52 : 10-18.

Url - jeu de données - Entrepôt autre : https://www.ebi.ac.uk/ena/data/view/PRJEB16347

Quartile : Q3, Sujet : INFECTIOUS DISEASES

Liste HCERES des revues (en SHS) : oui

Thème(s) HCERES des revues (en SHS) : Anthropologie-Ethnologie

Résumé : Microbiome studies generally focus on the gut microbiome, which is composed of a large proportion of commensal bacteria. Here we propose a first analysis of the liver microbiome using next generation sequencing as a tool to detect potentially pathogenic strains. We used Peromyscus leucopus, the main reservoir host species of Lyme disease in eastern North America, as a model and sequenced V5-V6 regions of the 16S gene from 18 populations in southern Quebec (Canada). The Lactobacillus genus was found to dominate the liver microbiome. We also detected a large proportion of individuals infected by Bartonella vinsonii arupensis, a human pathogenic bacteria responsible for endocarditis, as well as Borrelia burgdorferi, the pathogen responsible for Lyme disease in North America. We then compared the microbiomes among two P. leucopus genetic clusters occurring on either side of the St. Lawrence River, and did not detect any effect of the host genotype on their liver microbiome assemblage. Finally, we report, for the first time, the presence of B. burgdorferi in a small mammal host from the northern side of the St. Lawrence River, in support of models that have predicted the northern spread of Lyme disease in Canada.

Mots-clés Agrovoc : hôte, séquence nucléotidique, surveillance épidémiologique, agent pathogène, Bacteria, maladie infectieuse, Borrelia burgdorferi, bartonella, maladie de l'homme

Mots-clés géographiques Agrovoc : Québec, Amérique du Nord, Saint-Laurent

Classification Agris : 000 - Autres thèmes
L73 - Maladies des animaux

Champ stratégique Cirad : Axe 4 (2014-2018) - Santé des animaux et des plantes

Auteurs et affiliations

• André A., Université de Liège (BEL)
• Mouton Alice, Université de Liège (BEL)
• Millien Virginie, McGill University (CAN)
• Michaux Johan, CIRAD-ES-UPR AGIRs (FRA)

Source : Cirad-Agritrop (https://agritrop.cirad.fr/584272/)

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