Phytosterol vehicles used in a functional product modify carotenoid/cholesterol bioaccessibility and uptake by Caco-2 cells

Gies Magali, Servent Adrien, Borel Patrick, Dhuique-Mayer Claudie. 2020. Phytosterol vehicles used in a functional product modify carotenoid/cholesterol bioaccessibility and uptake by Caco-2 cells. Journal of Functional Foods, 68:103920, 8 p.

Quartile : Q1, Sujet : FOOD SCIENCE & TECHNOLOGY / Quartile : Q2, Sujet : NUTRITION & DIETETICS

Résumé : Functional foods containing dispersible phytosterols (DPs) are recommended to reduce cholesterol absorption in humans. However, only a few studies have been conducted on the effect of DP vehicles on carotenoid bioaccessibility and uptake by intestinal cells. On a previously developed fermented maize product containing both DPs and carotenoids, we aim to evaluate the effect of DPs encapsulated by maltodextrin on the carotenoid/phytosterol/cholesterol interactions during gastro-duodenal digestion. Thanks to maltodextrin properties, β-carotene and lycopene bioaccessibilities were significantly improved by 40.2 ± 1.4% while that of β-cryptoxanthin decreased by 14 ± 0.1%. Additionally, the presence of DPs reduced the cholesterol micellarization by 51.8 ± 4.2%. Despite a slight decrease in carotenoid uptake caused by the DP vehicle, related to micelle size, an inhibition of cholesterol accumulation by Caco-2 cells was observed. These results highlighted the key role of maltodextrin as a vehicle of DPs on carotenoid and cholesterol absorption.

Mots-clés Agrovoc : phytostérol, maltodextrine, absorption digestive, cholestérol, carotène, lycopène, caroténoïde

Mots-clés libres : Dispersible phytosterols, Maltodextrin, Carotenes, Xanthophylls, Bioaccessibility, Caco-2 cells

Classification Agris : S20 - Physiologie de la nutrition humaine

Champ stratégique Cirad : CTS 3 (2019-) - Systèmes alimentaires

Auteurs et affiliations

• Gies Magali, CIRAD-PERSYST-UMR Qualisud (FRA)
• Servent Adrien, CIRAD-PERSYST-UMR Qualisud (FRA) ORCID: 0000-0002-9670-6707
• Borel Patrick, INSERM (FRA)
• Dhuique-Mayer Claudie, CIRAD-PERSYST-UMR Qualisud (FRA) ORCID: 0000-0001-7153-2897 - auteur correspondant

Source : Cirad-Agritrop (https://agritrop.cirad.fr/595453/)

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