Genipap (Genipa americana L.) juice intake biomarkers after medium-term consumption

Dickson Livia, Tenon Mathieu, Svilar Ljubica, Fança-Berthon Pascale, Martin Jean-Charles, Rogez Hervé, Vaillant Fabrice. 2020. Genipap (Genipa americana L.) juice intake biomarkers after medium-term consumption. Food Research International, 137:109375, 8 p.

Quartile : Q1, Sujet : FOOD SCIENCE & TECHNOLOGY

Résumé : Genipap (Genipa americana L.) is an exotic fruit largely consumed and well known, in Amazonian pharmacopeia, to treat anemia, measles and uterine cancer. It is also used as a diuretic, digestive, healing, laxative and antiseptic. The aim of this study was to apply an untargeted metabolomics strategy to determine biomarkers of food intake after short-term consumption of genipap juice. Sixteen healthy adult men were administered jenipap juice (250 mL) twice a day for three weeks. Before and after the three weeks of consumption. the subjects drank a control drink, and they consumed a standard diet. Urine was collected after 0–6 h, 6–12 h and 12–24 h. An ultrahigh-performance liquid chromatography-mass spectrometry (UHPLC-MS)-based metabolomics approach was applied to analyze the urine samples. Principal components analysis (PCA) and partial least squares discriminant analysis (PLS-DA) were performed to highlight experimental differences between groups. The value of the area under the curve (AUC) of the receiver operator characteristic (ROC) curve validated the identified biomarkers. Thirty-one statistically affected urinary metabolites were putatively identified and were mainly related to iridoids family, medium-chain fatty acids, and polyphenols. Also a group of urinary markers including dihydrocaffeic acid (DHCA), 1-(4-hydroxyphenyl)-1,2-propanediol and 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid were established as biomarkers of genipap consumption. Our findings have established a comprehensive panel of changes in the urinary metabolome and provided information to monitor endogenous alterations that are linked to genipap juice intake. These data should be used in further studies to understand the health implications of genipap juice consumption.

Mots-clés Agrovoc : aliment santé pour homme, marqueur génétique, iridoïde, métabolite, jus de fruits, ingestion de substances nutritives, consommation alimentaire, urine

Mots-clés complémentaires : Genipa americana, Analyse en composantes principales

Mots-clés libres : Untargeted metabolomics, Urine, LC-MS, Food biomarkers intake, Iridoids, Exotic fruit

Classification Agris : S20 - Physiologie de la nutrition humaine
S50 - Santé humaine

Champ stratégique Cirad : CTS 3 (2019-) - Systèmes alimentaires

Auteurs et affiliations

• Dickson Livia, UFPA (BRA)
• Tenon Mathieu, Naturex (FRA)
• Svilar Ljubica, Université Aix-Marseille (FRA)
• Fança-Berthon Pascale, Naturex (FRA)
• Martin Jean-Charles, Université Aix-Marseille (FRA)
• Rogez Hervé, UFPA (BRA)
• Vaillant Fabrice, CIRAD-PERSYST-UMR Qualisud (COL) ORCID: 0000-0001-6318-1353 - auteur correspondant

Source : Cirad-Agritrop (https://agritrop.cirad.fr/599767/)

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