Antimicrobial residues in meat from chickens in Northeast Vietnam: analytical validation and pilot study for sampling optimisation

Hedges Sophie, Pelligand Ludovic, Chen Liwei, Seow Kelyn, Hoang Thuy Tien, Luu Huong Quynh, Dang Son Thi Thanh, Pham Ngoc Thi, Pham Hoa Thi Thanh, Cheah Yeong Cheng, Wang Yulan, Hurtaud-Pessel Dominique, Conan Anne, Fournié Guillaume, Blake Damer, Tomley Fiona, Conway Patricia L.. 2024. Antimicrobial residues in meat from chickens in Northeast Vietnam: analytical validation and pilot study for sampling optimisation. Journal of Consumer Protection and Food Safety, 19 : 225-134.

http://doi.org/10.1007/s00003-024-01478-9

Article de revue ; Article de recherche ; Article de revue à facteur d'impact

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Résumé : Antimicrobials used in chicken farming for therapeutic and/or prophylactic purposes may result in unacceptable levels of edible residues, if withdrawal periods are not respected. To evaluate the risk in Vietnam, we validated an analytical method to detect antimicrobial residues from chicken meat samples and carried out a pilot cross-sectional study to identify optimal sampling strategies. A total of 45 raw meat samples were collected from 4 markets, 1 slaughterhouse and 4 farms (5 per site) in Northern Vietnam, between March and April 2021. Farmers were asked about antimicrobials used during sampled production cycles (5 chickens sampled per batch). Samples were analysed using liquid chromatography-tandem mass spectrometry for the presence of 68 antimicrobials at a pre-defined validation concentration. 7 compounds were identified from 4 classes (tetracyclines, sulphonamides, macrolides, and fluoroquinolones). In markets, where the source of sampled chickens was unknown, a diverse pool of residual antimicrobials was detected in 20% (4/20) of the meat samples. No residues were detected in samples from the slaughterhouse. No residues were detected in chickens from the one farm that reported using antimicrobials, whereas sulfadimethoxine, doxycycline and tilmicosin residues were identified from the other 3 farms reporting no antimicrobial use. The probability of detecting antimicrobial residues present in a flock based on sampling a single chicken was estimated at 0.93 (highest density interval 0.735–0.997). The preliminary results suggest a disparity between farmers' reports on antimicrobial drug use and actual usage, and that the analysis of a single sample per farm has a high probability of detecting antimicrobial residues, if present.

Mots-clés Agrovoc : poulet, technique analytique, sulfadiméthoxine, antimicrobien, prophylaxie des maladies, recherche interdisciplinaire, résidu de médicament, résidu de médicament vétérinaire

Mots-clés géographiques Agrovoc : Viet Nam

Mots-clés libres : Poultry market, Chicken farm, Antibiotic residues, Maximal residue limit, Withdrawal period, LC–MS/MS

Classification Agris : Q03 - Contamination et toxicologie alimentaires
Q04 - Composition des produits alimentaires

Champ stratégique Cirad : CTS 3 (2019-) - Systèmes alimentaires

Agences de financement hors UE : UK Research and Innovation

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