Genetic diversity and population structure of the secondary symbiont of tsetse flies, sodalis glossinidius, in sleeping sickness foci in Cameroon

Farikou Oumarou, Thevenon Sophie, Njiokou Flobert, Allal François, Cuny Gérard, Geiger Anne. 2011. Genetic diversity and population structure of the secondary symbiont of tsetse flies, sodalis glossinidius, in sleeping sickness foci in Cameroon. PLoS Neglected Tropical Diseases, 5 (8):e1281, 9 p.

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Quartile : Q1, Sujet : TROPICAL MEDICINE / Quartile : Q1, Sujet : PARASITOLOGY

Abstract : Background: Previous studies have shown substantial differences in Sodalis glossinidius and trypanosome infection rates between Glossina palpalis palpalis populations from two Cameroonian foci of human African trypanosomiasis (HAT), Bipindi and Campo. We hypothesized that the geographical isolation of the two foci may have induced independent evolution in the two areas, resulting in the diversification of symbiont genotypes. Methodology/Principal Findings: To test this hypothesis, we investigated the symbiont genetic structure using the allelic size variation at four specific microsatellite loci. Classical analysis of molecular variance (AMOVA) and differentiation statistics revealed that most of the genetic diversity was observed among individuals within populations and frequent haplotypes were shared between populations. The structure of genetic diversity varied at different geographical scales, with almost no differentiation within the Campo HAT focus and a low but significant differentiation between the Campo and Bipindi HAT foci. Conclusions/Significance: The data provided new information on the genetic diversity of the secondary symbiont population revealing mild structuring. Possible interactions between S. glossinidius subpopulations and Glossina species that could favor tsetse fly infections by a given trypanosome species should be further investigated. (Résumé d'auteur)

Mots-clés Agrovoc : Glossina palpalis, Enterobacteriaceae, Variation génétique, Génome, Symbiote, Flux de gènes, Trypanosomose

Mots-clés géographiques Agrovoc : Cameroun

Mots-clés complémentaires : Sodalis glossinidius, Glossina palpalis palpalis, Structure génétique

Classification Agris : L72 - Pests of animals
L73 - Animal diseases

Champ stratégique Cirad : Axe 4 (2005-2013) - Santé animale et maladies émergentes

Auteurs et affiliations

  • Farikou Oumarou, Université de Yaoundé 1 (CMR)
  • Njiokou Flobert, Université de Yaoundé 1 (CMR)
  • Allal François, CIRAD-BIOS-UMR AGAP (COG)
  • Cuny Gérard, IRD (FRA)
  • Geiger Anne, IRD (FRA)

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