Yersinia pestis genome sequencing identifies patterns of global phylogenetic diversity

Morelli Giovanna, Song Yajun, Mazzoni Camila J., Eppinger Mark, Roumagnac Philippe, Wagner David.M., Feldkamp Mirjam, Kusecek Barica, Vogler Amy. J., Li Yanjun, Cui Yujun, Thomson Nicholas R, Jombart Thibaut, Leblois Raphaël, Lichtner Peter, Rahalison Lila, Petersen Jeannine M, Balloux François, Keim Paul, Wirth Thierry, Ravel Jacques, Yang Ruifu, Carniel Elisabeth, Achtman Mark. 2010. Yersinia pestis genome sequencing identifies patterns of global phylogenetic diversity. Nature Genetics, 42 (12) : pp. 1140-1143.

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Quartile : Outlier, Sujet : GENETICS & HEREDITY

Liste HCERES des revues (en SHS) : oui

Thème(s) HCERES des revues (en SHS) : Psychologie-éthologie-ergonomie

Abstract : Plague is a pandemic human invasive disease caused by the bacterial agent Yersinia pestis. We here report a comparison of 17 whole genomes of Y. pestis isolates from global sources. We also screened a global collection of 286 Y. pestis isolates for 933 SNPs using Sequenom MassArray SNP typing. We conducted phylogenetic analyses on this sequence variation dataset, assigned isolates to populations based on maximum parsimony and, from these results, made inferences regarding historical transmission routes. Our phylogenetic analysis suggests that Y. pestis evolved in or near China and spread through multiple radiations to Europe, South America, Africa and Southeast Asia, leading to country-specific lineages that can be traced by lineage-specific SNPs. All 626 current isolates from the United States reflect one radiation, and 82 isolates from Madagascar represent a second radiation. Subsequent local microevolution of Y. pestis is marked by sequential, geographically specific SNPs. (Résumé d'auteur)

Mots-clés Agrovoc : Yersinia pestis, Phylogénie, Génome, Variation génétique, Maladie de l'homme

Mots-clés géographiques Agrovoc : Monde

Classification Agris : L73 - Animal diseases
000 - Other themes

Champ stratégique Cirad : Axe 4 (2005-2013) - Santé animale et maladies émergentes

Auteurs et affiliations

  • Morelli Giovanna, Max-Planck Institut für Infektionsbiologie (DEU)
  • Song Yajun, UCC (IRL)
  • Mazzoni Camila J., UCC (IRL)
  • Eppinger Mark, University of Maryland (USA)
  • Roumagnac Philippe, CIRAD-BIOS-UMR BGPI (FRA) ORCID: 0000-0001-5002-6039
  • Wagner David.M., University of Arizona (USA)
  • Feldkamp Mirjam, Max-Planck Institut für Infektionsbiologie (DEU)
  • Kusecek Barica, Max-Planck Institut für Infektionsbiologie (DEU)
  • Vogler Amy. J., University of Arizona (USA)
  • Li Yanjun, Institute of Microbiology and Epidemiology (CHN)
  • Cui Yujun, Institute of Microbiology and Epidemiology (CHN)
  • Thomson Nicholas R, Wellcome Trust Sanger Institute (GBR)
  • Jombart Thibaut, Imperial college faculty of medicine (GBR)
  • Leblois Raphaël, MNHN (FRA)
  • Lichtner Peter, Institute of Human Genetics (DEU)
  • Rahalison Lila, Institut Pasteur de Madagascar (MDG)
  • Petersen Jeannine M, CDC (USA)
  • Balloux François, Imperial college faculty of medicine (GBR)
  • Keim Paul, University of Arizona (USA)
  • Wirth Thierry, MNHN (FRA)
  • Ravel Jacques, University of Maryland (USA)
  • Yang Ruifu, Institute of Microbiology and Epidemiology (CHN)
  • Carniel Elisabeth, Institut Pasteur (FRA)
  • Achtman Mark, UCC (IRL)

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