Genetic diversity of human rhinoviruses in Cambodia during a three-year period reveals novel genetic types

Naughtin Monica, Rith Sareth, Sentilhes Anne-Charlotte, Vong Sirenda, Joffret Marie-Line, Cornillot Emmanuel, Deubel Vincent, Delpeyroux Francis, Frutos Roger, Buchy Philippe. 2015. Genetic diversity of human rhinoviruses in Cambodia during a three-year period reveals novel genetic types. Infection, Genetics and Evolution, 35 : 42-49.

Quartile : Q2, Sujet : INFECTIOUS DISEASES

Liste HCERES des revues (en SHS) : oui

Thème(s) HCERES des revues (en SHS) : Anthropologie-Ethnologie

Résumé : Acute respiratory viral infections are a major cause of morbidity during early childhood in developing countries. Human rhinoviruses are the most frequent cause of upper respiratory tract infections in humans, which can range in severity from asymptomatic to clinically severe disease. In this study we collected 4170 nasopharyngeal swabs from patients hospitalised with influenza-like illness in two Cambodian provincial hospitals between 2007 and 2010. Samples were screened for 18 respiratory viruses using 5 multiplex PCRs. A total of 11.2% of samples tested positive for human rhinoviruses (HRV). VP4/2 and VP1 regions were amplified and sequenced to study the distribution of rhinoviruses genotypes and species in Cambodia during this three-year period. Five novel genotypes, 2 species A, 2 species B and 1 species C were identified based on VP1 sequences. Co-infections with other viruses were demonstrated.

Mots-clés Agrovoc : Rhinovirus, variation génétique, génétique des populations, Picornaviridae, genre humain, maladie de l'homme, séquence nucléotidique, virologie

Mots-clés géographiques Agrovoc : Cambodge

Classification Agris : S50 - Santé humaine

Champ stratégique Cirad : Axe 4 (2014-2018) - Santé des animaux et des plantes

Auteurs et affiliations

• Naughtin Monica, Institut Pasteur du Cambodge (KHM)
• Rith Sareth, Institut Pasteur du Cambodge (KHM)
• Sentilhes Anne-Charlotte, Institut Pasteur du Cambodge (KHM)
• Vong Sirenda, Institut Pasteur du Cambodge (KHM)
• Joffret Marie-Line, Institut Pasteur (FRA)
• Cornillot Emmanuel, Institut de Biologie Computationnelle (FRA)
• Deubel Vincent, Institut Pasteur du Cambodge (KHM)
• Delpeyroux Francis, Institut Pasteur (FRA)
• Frutos Roger, CIRAD-BIOS-UMR INTERTRYP (FRA)
• Buchy Philippe, Institut Pasteur du Cambodge (KHM)

Source : Cirad-Agritrop (https://agritrop.cirad.fr/577380/)

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