Rice bran lipidome identifies novel phospholipids, glycolipids and oxylipins with roles in lipid metabolism of hypercholesterolemic children

Barros Santos Millena, Barouh Nathalie, Lullien-Pellerin Valérie, Micard Valérie, Villeneuve Pierre, Zhou Bingqing, Oger Camille, Vigor Claire, Durand Thierry, Larraz Ferreira Mariana Simões, Bourlieu-Lacanal Claire, Ryan Elizabeth P.. 2023. Rice bran lipidome identifies novel phospholipids, glycolipids and oxylipins with roles in lipid metabolism of hypercholesterolemic children. Molecular Nutrition and Food Research, 67 (6):2200111, 13 p.

Liste HCERES des revues (en SHS) : oui

Thème(s) HCERES des revues (en SHS) : Psychologie-éthologie-ergonomie

Résumé : Scope: The purpose of the study is to characterize the chemical diversity in Rice bran (RB) lipidome and determine whether daily RB consumption for 4 weeks may modulate plasma lipid profiles in children. Methods and Results: Untargeted and targeted lipidomics via ultra-performance liquid chromatography coupled with high-resolution tandem mass spectrometry (UPLC-MS/MS) were applied to identify bioactive RB lipids from a collection of 17 rice varieties. To determine the impact of RB (Calrose-USA variety) supplementation on plasma lipid profile, a secondary analysis of plasma lipidome was conducted on data recorded in a clinical study (NCT01911390, n = 18 moderately hypercholesterolemic children) before and after 4 weeks of dietary intervention (15 g/d) with a control or RB supplemented snack. Untargeted lipidomic revealed 118 lipids as the core of lipidome across all 17 varieties among which phospholipids were abundant and oxylipins present. Phytoprostanes and phytofurans were quantified and characterized. Lipidome analysis of the children plasma following RB consumption revealed the presence of novel polar lipids and oxylipins alongside putative modulations in endocannabinoids associated with RB consumption. Conclusion: The investigation of novel polar lipids, oxylipins, phytoprostanes, and phytofurans in RB extracts provides support for new health-promoting properties especially interesting for people at risk for cardiometabolic disease.

Mots-clés Agrovoc : glycolipide, acide gras, métabolisme des lipides, métabolisme des phospholipides, lipide, enfant, phosphatide, son de riz, composition des aliments

Mots-clés géographiques Agrovoc : Cambodge, Mali

Mots-clés libres : Bioactive lipids, Omics, Polar lipids, Phytoprostanes, Phytofurans, Rice branlipids

Classification Agris : Q04 - Composition des produits alimentaires
S50 - Santé humaine

Champ stratégique Cirad : CTS 3 (2019-) - Systèmes alimentaires

Agences de financement hors UE : National Institute of Food and Agriculture, Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro, Conselho Nacional de Desenvolvimento Científico e Tecnológico

Projets sur financement : (USA) Rice bran and bean metabolomes for human dietary exposure biomarkers

Auteurs et affiliations

• Barros Santos Millena, UFRJ (BRA)
• Barouh Nathalie, CIRAD-PERSYST-UMR Qualisud (FRA) ORCID: 0000-0001-6956-1349
• Lullien-Pellerin Valérie, INRAE (FRA)
• Micard Valérie, Université de Montpellier (FRA)
• Villeneuve Pierre, CIRAD-PERSYST-UMR Qualisud (FRA) ORCID: 0000-0003-1685-1494
• Zhou Bingqing, IBMM (FRA)
• Oger Camille, IBMM (FRA)
• Vigor Claire, IBMM (FRA)
• Durand Thierry, IBMM (FRA)
• Larraz Ferreira Mariana Simões, UNIRIO (BRA)
• Bourlieu-Lacanal Claire, CIRAD-PERSYST-UMR Qualisud (FRA) - auteur correspondant
• Ryan Elizabeth P., Colorado State University (USA) - auteur correspondant

Source : Cirad-Agritrop (https://agritrop.cirad.fr/603134/)

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