Awara (Astrocaryum vulgare M.) pulp oil: Chemical characterization, and anti-inflammatory properties in a mice model of endotoxic shock and a rat model of pulmonary inflammation

Bony Emilie, Boudard Frédéric, Brat Pierre, Dussossoy Emilie, Portet Karine, Poucheret Patrick, Giaimis Jean, Michel Alain. 2012. Awara (Astrocaryum vulgare M.) pulp oil: Chemical characterization, and anti-inflammatory properties in a mice model of endotoxic shock and a rat model of pulmonary inflammation. Fitoterapia, 83 (1) : 33-43.

https://doi.org/10.1016/j.fitote.2011.09.007

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Quartile : Q2, Sujet : PHARMACOLOGY & PHARMACY / Quartile : Q3, Sujet : CHEMISTRY, MEDICINAL

Liste HCERES des revues (en SHS) : oui

Thème(s) HCERES des revues (en SHS) : Psychologie-éthologie-ergonomie

Résumé : Awara (Astrocaryum vulgare M.) is a palm fruit mainly used in nutrition. We analysed the pulp oil for fatty acid, tocopherol, carotenoid, and phytosterol and we evaluated whether this oil may attenuate inflammation in vivo. In an endotoxic shock model, awara pulp oil treatment decreased pro-inflammatory cytokines and increased anti-inflammatory cytokines. In a pulmonary inflammation model, awara pulp oil treatment reduced eosinophil and lymphocyte numbers recovered into the broncho-alveolar lavages. These results suggest that awara pulp oil administration can efficiently counteract an acute and chronic inflammatory response in vivo that is probably mediated by fatty acids and minor compounds.

Mots-clés Agrovoc : Astrocaryum, huile végétale, anti-inflammatoire, rat, propriété pharmacologique, composition chimique, caroténoïde, acide gras, tocophérol, phytostérol, Astrocaryum vulgare