Dilobenol A-G, Diprenylated Dihydroflavonols from the Leaves of Dilobeia thouarsii

Razafintsalama Voahiraniaina, Girardot Marion, Randrianarivo Ranjana, Rakoto Danielle, Sarter Samira, Petit Thomas, Ralambonirina Sylvia, Deville Alexandre, Grellier Philippe, Jeannoda Victor, Mambu Lengo. 2013. Dilobenol A-G, Diprenylated Dihydroflavonols from the Leaves of Dilobeia thouarsii. European Journal of Organic Chemistry, 2013 (10) : 1929-1936.

https://doi.org/10.1002/ejoc.201201421

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Quartile : Q1, Sujet : CHEMISTRY, ORGANIC

Résumé : The study of the EtOAc extract of the leaves of Dilobeia thouarsii led to the isolation and identification of seven new diprenylated dihydroxyflavonols named dilobenol A-G (1-7). Their structures were elucidated by spectroscopic analysis including UV, IR, 1D and 2D NMR and MS as well as by chemical hydrolysis. The isolated compounds were assessed for their antibacterial, antiplasmodial and cytotoxic activities. They exhibited moderate growth inhibitory activities against Staphylococcus aureus, Vibrio spp., Bacillus spp, and Plasmodium falciparum without significant toxicity against mammalian cell line L-6.

Mots-clés Agrovoc : Proteaceae, plante médicinale, flavonoïde, extrait d'origine végétale, feuille, antiprotozoaire, antimicrobien, propriété antimicrobienne, toxicité, Vibrio, Plasmodium falciparum, Bacillus, Staphylococcus aureus, structure chimique, spectrométrie