Hypoglycaemic, hypolipidaemic and antioxidant effects of blackberry beverage consumption in streptozotocin-induced diabetic rats

Azofeifa Gabriela, Quesada Silvia, Navarro Laura, Hidalgo Olman, Portet Karine, Pérez Ana Mercedes, Vaillant Fabrice, Poucheret Patrick, Michel Alain. 2016. Hypoglycaemic, hypolipidaemic and antioxidant effects of blackberry beverage consumption in streptozotocin-induced diabetic rats. Journal of Functional Foods, 26 : 330-337.

Quartile : Q1, Sujet : FOOD SCIENCE & TECHNOLOGY

Résumé : Abnormal glucose metabolism, hyperlipidaemia profiles and high levels of radical oxygen species (ROS) are classic features of diabetes. This study evaluates the effect of the consumption of two different blackberry beverages at 25 and 12.5% given orally for 40 days to rats with streptozotocin induced diabetes. The lower dose of blackberry (12.5%) non-statistically decreased glycaemia (−10.4%), triacylglycerols (−4.6%) and cholesterol (−21.0%). These differences were not statistically significant. The higher dose of blackberry (25%) significantly decreased glucose (−48.6%), triacylglycerols (−43.5%) and cholesterol (−28.6%). The higher dose of blackberry (25%) improved plasma antioxidant capacity, reduced the levels of lipid peroxidation in plasma (−19%) and in kidney (−23%). Blackberry intake did not improve catalase, suggesting that attenuation of oxidative stress via scavenging activities rather than improving the activities of antioxidant enzymes. These results provide promising data for this blackberry as a dietary adjuvant to the pharmacological management of diabetes.

Mots-clés Agrovoc : antioxydant, cholestérol, hyperlipidémie, rat, consommation d'oxygène, mûre de ronce, activité enzymatique, boisson

Classification Agris : Q04 - Composition des produits alimentaires
L51 - Physiologie animale - Nutrition
L70 - Sciences et hygiène vétérinaires - Considérations générales

Champ stratégique Cirad : Axe 3 (2014-2018) - Alimentation durable

Auteurs et affiliations

• Azofeifa Gabriela, UCR (CRI)
• Quesada Silvia, UCR (CRI)
• Navarro Laura, UCR (CRI)
• Hidalgo Olman, Université de Montpellier (FRA)
• Portet Karine, Université de Montpellier (FRA)
• Pérez Ana Mercedes, UCR (CRI)
• Vaillant Fabrice, CIRAD-PERSYST-UMR Qualisud (COL) ORCID: 0000-0001-6318-1353
• Poucheret Patrick, Université de Montpellier (FRA)
• Michel Alain, UM1 (FRA)

Source : Cirad-Agritrop (https://agritrop.cirad.fr/583640/)

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