Faecal microbiota of schoolchildren is associated with nutritional status and markers of inflammation: a double-blinded cluster-randomized controlled trial using multi-micronutrient fortified rice

Seyoum Yohannes, Greffeuille Valérie, Kouadio Dorgeles Kouakou Dje, Kuong Khov, Turpin Williams, M'Rabt Rachida, Chochois Vincent, Fortin Sonia, Perignon Marlène, Fiorentino Marion, Berger Jacques, Burja Kurt, Ponce Maiza Campos, Chamnan Chhoun, Wieringa Frank T., Humblot Christèle. 2024. Faecal microbiota of schoolchildren is associated with nutritional status and markers of inflammation: a double-blinded cluster-randomized controlled trial using multi-micronutrient fortified rice. Nature Communications, 15:5204, 12 p.

Url - jeu de données - Entrepôt autre : https://www.ncbi.nlm.nih.gov/bioproject/882252 / Url - autres données associées : https://github.com/yoh-s/FORISCA

Résumé : Faecal microbiota plays a critical role in human health, but its relationship with nutritional status among schoolchildren remains under-explored. Here, in a double-blinded cluster-randomized controlled trial on 380 Cambodian schoolchildren, we characterize the impact of six months consumption of two types of rice fortified with different levels of vitamins and minerals on pre-specified outcomes. We investigate the association between the faecal microbiota (16SrRNA sequencing) and age, sex, nutritional status (underweight, stunting), micronutrient status (iron, zinc and vitamin A deficiencies, anaemia, iron deficient anaemia, hemoglobinopathy), inflammation (systemic, gut), and parasitic infection. We show that the faecal microbiota is characterised by a surprisingly high proportion of Lactobacillaceae. We discover that deficiencies in specific micronutrients, such as iron and vitamin A, correlate with particular microbiota profiles, whereas zinc deficiency shows no such association. The nutritional intervention with the two rice treatments impacts both the composition and functions predicted from compositional analysis in different ways. (ClinicalTrials.gov (Identifier: NCT01706419)).

Mots-clés Agrovoc : flore microbienne, Lactobacillaceae, oligo-élement, enfant en âge scolaire, zinc, nutrition humaine, fer, enfant, surveillance épidémiologique, riz, vitamine E, anémie, carence en vitamine

Mots-clés géographiques Agrovoc : Cambodge, La Réunion

Mots-clés libres : Malnutrition, Metagenomics

Agences de financement hors UE : United States Department of Labor, Institut de Recherche pour le Développement

Auteurs et affiliations

• Seyoum Yohannes, Avignon Université (FRA)
• Greffeuille Valérie, IRD (FRA)
• Kouadio Dorgeles Kouakou Dje, IRD (FRA)
• Kuong Khov, Ministry of Agriculture, Forestry and Fisheries (Cambodge) (KHM)
• Turpin Williams, Université de Toronto (CAN)
• M'Rabt Rachida, Avignon Université (FRA)
• Chochois Vincent, CIRAD-PERSYST-UMR Qualisud (FRA) ORCID: 0000-0003-1348-9936
• Fortin Sonia, IRD (FRA)
• Perignon Marlène, INRAE (FRA)
• Fiorentino Marion, IRD (FRA)
• Berger Jacques, IRD (FRA)
• Burja Kurt, United Nations World Food Programme (KHM)
• Ponce Maiza Campos, University of Amsterdam (NLD)
• Chamnan Chhoun, Ministry of Agriculture, Forestry and Fisheries (Cambodge) (KHM)
• Wieringa Frank T., IRD (FRA)
• Humblot Christèle, IRD (FRA) - auteur correspondant

Source : Cirad-Agritrop (https://agritrop.cirad.fr/612940/)

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