Oral administration of Costa Rican guava (Psidium friedrichsthalianum) juice induces changes in urinary excretion of energy-related compounds in Wistar rats determined by 1H NMR

Montoya-Arroyo Alexander, Díaz Cecilia, Vaillant Fabrice, Tamayo-Castillo Giselle. 2020. Oral administration of Costa Rican guava (Psidium friedrichsthalianum) juice induces changes in urinary excretion of energy-related compounds in Wistar rats determined by 1H NMR. NFS Journal, 20 : 48-57.

https://doi.org/10.1016/j.nfs.2020.07.003

Article de revue ; Article de recherche ; Article de revue à comité de lecture

Prévisualisation

Version publiée - Anglais
Sous licence

.
614806.pdf
Télécharger (906kB) | Prévisualisation

Résumé : Introduction: Psidium friedrichsthalianum fruits have in vitro antioxidant activity and their intake has been suggested to have potential health benefits; however, there is still no evidence on the potential in vivo effect of their consumption. Objective: We aim to study the effect of the oral administration of a P. friedrichsthalianum juice on the urinary metabolome of adult male Wistar rats. Methods: Acute and short-term interventions were carried out and urine sample metabolites were analyzed in a 600 MHz NMR instrument with a NOESY-presat sequence.and post-treatment effects were identified by comparison against control conditions. Results: Acute administration caused a decrease in the excretion of citrate and allantoin in the 0 to 6 h period and citrate and α-ketoglutarate in the 6 to 12 h period. Lactate and Krebs cycle intermediates showed reduced excretion in the 12 to 24 h period. Short-term administration (for 7 days) decreased the excretion of Krebs cycle intermediates together with lactate and allantoin. The effect was stronger after short-term administration suggesting a dose-dependent effect. Conclusion: P. friedrichsthalianum juice caused a change in rat excretion of energy metabolites, probably associated with an increase in aerobic metabolism, suggesting in vivo modulation of the redox balance.

Mots-clés Agrovoc : jus de fruits, rat, antioxydant, allantoïne, cycle tricarboxylique, composition chimique, urine, Hibiscus sabdariffa, métabolisme

Mots-clés géographiques Agrovoc : Costa Rica

Mots-clés libres : Psidium friedrichsthalianum, Urine metabolomics, Phytochemicals, Redox balance, 1H NMR

Agences de financement hors UE : Universidad de Costa Rica

Auteurs et affiliations