Gonzalez Gaëlle, Bournez Laure, Moares Rayane Amaral, Dumarest Marine, Galon Clémence, Vorimore Fabien, Cochin Maxime, Nougairède Antoine, Hennechart-Collette Catherine, Perelle Sylvie, Leparc-Goffart Isabelle, Durand Guillaume André, Grard Gilda, Bénet Thomas, Danjou Nathalie, Blanchin Martine, Lacour Sandrine A., Boué Franck, Chenut Guillaume, Mainguet Catherine, Simon Catherine, Brémont Laurence, Zientara Stéphan, Moutailler Sara, Martin-Latil Sandra, Dheilly Nolwenn M., Beck Cécile, Lecollinet Sylvie. 2022. A one-health approach to investigating an outbreak of alimentary tick-borne encephalitis in a non-endemic area in France (Ain, Eastern France): A longitudinal serological study in livestock, detection in ticks, and the first tick-borne encephalitis virus isolation and molecular characterisation. Frontiers in Microbiology, 13:863725, 15 p.
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Url - jeu de données - Entrepôt autre : https://figshare.com/collections/A_One-Health_Approach_to_Investigating_an_Outbreak_of_Alimentary_Tick-Borne_Encephalitis_in_a_Non-endemic_Area_in_France_Ain_Eastern_France_A_Longitudinal_Serological_Study_in_Livestock_Detection_in_Ticks_and_the_First_Tic
Résumé : Tick-borne encephalitis virus' (TBEV) geographic range and the human incidence are increasing throughout Europe, putting a number of non-endemic regions and countries at risk of outbreaks. In spring 2020, there was an outbreak of tick-born encephalitis (TBE) in Ain, Eastern France, where the virus had never been detected before. All patients but one had consumed traditional unpasteurised raw goat cheese from a local producer. We conducted an investigation in the suspected farm using an integrative One Health approach. Our methodology included (i) the detection of virus in cheese and milk products, (ii) serological testing of all animals in the suspected farm and surrounding farms, (iii) an analysis of the landscape and localisation of wooded area, (iv) the capture of questing ticks and small mammals for virus detection and estimating enzootic hazard, and (v) virus isolation and genome sequencing. This approach allowed us to confirm the alimentary origin of the TBE outbreak and witness in real-time the seroconversion of recently exposed individuals and excretion of virus in goat milk. In addition, we identified a wooded focus area where and around which there is a risk of TBEV exposure. We provide the first TBEV isolate responsible for the first alimentary-transmitted TBE in France, obtained its full-length genome sequence, and found that it belongs to the European subtype of TBEV. TBEV is now a notifiable human disease in France, which should facilitate surveillance of its incidence and distribution throughout France.
Mots-clés Agrovoc : encéphalite à tiques, maladie transmissible par tiques, maladie de l'homme, fromage de chèvre, lait cru, aliment biologique, Enquête pathologique, surveillance épidémiologique
Mots-clés géographiques Agrovoc : France
Mots-clés complémentaires : approche "une seule santé"
Mots-clés libres : Tick-borne encephalitis virus, One Health, Integrated surveillance, Food-borne infection
Classification Agris : S50 - Santé humaine
S30 - Régimes alimentaires et maladies nutritionnelles
Champ stratégique Cirad : CTS 4 (2019-) - Santé des plantes, des animaux et des écosystèmes
Auteurs et affiliations
- Gonzalez Gaëlle, ANSES (FRA) - auteur correspondant
- Bournez Laure, ANSES (FRA) - auteur correspondant
- Moares Rayane Amaral, ANSES (FRA)
- Dumarest Marine, ANSES (FRA)
- Galon Clémence, ANSES (FRA)
- Vorimore Fabien, ANSES (FRA)
- Cochin Maxime, Université Aix-Marseille (FRA)
- Nougairède Antoine, Université Aix-Marseille (FRA)
- Hennechart-Collette Catherine, Université Paris-Est (FRA)
- Perelle Sylvie, Université Paris-Est (FRA)
- Leparc-Goffart Isabelle, Université Aix-Marseille (FRA)
- Durand Guillaume André, Université Aix-Marseille (FRA)
- Grard Gilda, Université Aix-Marseille (FRA)
- Bénet Thomas, Santé Publique France (FRA)
- Danjou Nathalie, Agence régionale de santé Auvergne Rhône Alpes (FRA)
- Blanchin Martine, Agence régionale de santé Auvergne Rhône Alpes (FRA)
- Lacour Sandrine A., INRAE (FRA)
- Boué Franck, ANSES (FRA)
- Chenut Guillaume, Direction Départementale de la Protection de la Population de l'Ain (FRA)
- Mainguet Catherine, Direction Départementale de la Protection de la Population de l'Ain (FRA)
- Simon Catherine, Direction Départementale de la Protection de la Population de l'Ain (FRA)
- Brémont Laurence, Direction Départementale de la Protection de la Population de l'Ain (FRA)
- Zientara Stéphan, ANSES (FRA)
- Moutailler Sara, ANSES (FRA)
- Martin-Latil Sandra, Université Paris-Est (FRA)
- Dheilly Nolwenn M., INRAE (FRA)
- Beck Cécile, ANSES (FRA)
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Lecollinet Sylvie, CIRAD-BIOS-UMR ASTRE (GLP)
ORCID: 0000-0001-8535-2133
Source : Cirad-Agritrop (https://agritrop.cirad.fr/601573/)
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