Main urinary biomarkers of golden berries (Physalis peruviana) following acute and short-term nutritional intervention in healthy human volunteers

Vaillant Fabrice, Llano Gil Sandra Milena, Martín Alberto Ángel, Moreno-Castellanos Natalia. 2023. Main urinary biomarkers of golden berries (Physalis peruviana) following acute and short-term nutritional intervention in healthy human volunteers. Food Research International, 173 (2):113443, 10 p.

Résumé : The metabolites entering the bloodstream and being excreted in urine as a result of consuming golden berries are currently unidentified. However, these metabolites potentially underlie the health benefits observed in various in vitro, animal, and human models. A nutritional intervention with 18 healthy human volunteers was performed, and urine was collected at baseline and after acute and short-term fruit consumption for 19 days. After UPLC-ESI/QToF-MS analysis, untargeted metabolomics was performed on the urine samples, and from the 50 most discriminant ions (VIP > 2) generated by a validated PLS-DA model (CV-ANOVA = 3.7e-35; R^2Y = 0.86, Q^2Y = 0.62 and no overfitting), 22 compounds were identified with relatively high confidence. The most discriminant metabolites confirmed by DHS/GC-MS2 analysis of volatiles in urine were sesquiterpenes (C15H22): 3 stereoisomers, β-vatirenene, β-vetivenene, and β-vetispirene, and 2 isomers, eremophila-1(10),8,11-triene and α-curcumene. Another major urinary biomarker was 4β-hydroxywithanolide E and its phase II derivatives, which were observed in urine for all individual up to 24 h after the fruit was consumed; thus, the bioavailability of this biomarker in humans was demonstrated for the first time. Additionally, the excretion of certain acylcarnitines and hypoxanthine in urine increased after golden berry consumption, which may be associated with a detoxifying effect and may occur because fats were utilized rather than carbohydrates to meet the body's energy needs. The main biomarkers of golden berry consumption are specific to this fruit, confirming its potential for the functional food market.

Mots-clés Agrovoc : Physalis, nutrition humaine, urine, consommation alimentaire, Physalis peruviana

Mots-clés géographiques Agrovoc : Colombie

Mots-clés libres : Physalis peruviana, Withanolides, Sesquiterpenoids

Classification Agris : Q04 - Composition des produits alimentaires
Q01 - Sciences et technologies alimentaires - Considérations générales

Champ stratégique Cirad : CTS 3 (2019-) - Systèmes alimentaires

Agences de financement hors UE : Corporación colombiana de investigación agropecuaria, Ministerio de Agricultura y Desarrollo Rural

Projets sur financement : (COL) Comprehensive development of sus- tainable production models for the cultivation of cape gooseberry in Colombia

Auteurs et affiliations

• Vaillant Fabrice, CIRAD-PERSYST-UMR Qualisud (COL) ORCID: 0000-0001-6318-1353 - auteur correspondant
• Llano Gil Sandra Milena, CIRAD-PERSYST-UMR Qualisud (FRA)
• Martín Alberto Ángel, Universidad Industrial de Santander (COL)
• Moreno-Castellanos Natalia, Universidad Industrial de Santander (COL)

Source : Cirad-Agritrop (https://agritrop.cirad.fr/608629/)

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