Low-frequency somatic mutations are heritable in tropical trees Dicorynia guianensis and Sextonia rubra

Schmitt Sylvain, Heuret Patrick, Troispoux Valérie, Beraud Mélmanie, Cazal Jocelyn, Chancerel Emilie, Cravero Charlotte, Guichoux Erwan, Lepais Olivier, Loureiro João, Marande William, Martin-Ducup Olivier, Vincent Grégoire, Chave Jérôme, Plomion Christophe, Leroy Thibault, Heuertz Myriam, Tysklind Niklas. 2024. Low-frequency somatic mutations are heritable in tropical trees Dicorynia guianensis and Sextonia rubra. Proceedings of the National Academy of Sciences of the United States of America, 121 (10):e2313312121, 7 p.

Url - jeu de données - Entrepôt autre : https://dataview.ncbi.nlm.nih.gov/object/PRJNA823677 / Url - jeu de données - Entrepôt autre : https://www.genoscope.cns.fr/plants / Url - jeu de données - Entrepôt autre : https://www.ebi.ac.uk/ena/browser/view/PRJEB70295 / Url - autres données associées : https://doi.org/10.5281/zenodo.10090430 / Url - autres données associées : https://doi.org/10.5281/zenodo.10089692

Liste HCERES des revues (en SHS) : oui

Thème(s) HCERES des revues (en SHS) : Economie-gestion; Psychologie-éthologie-ergonomie

Résumé : Somatic mutations potentially play a role in plant evolution, but common expectations pertaining to plant somatic mutations remain insufficiently tested. Unlike in most animals, the plant germline is assumed to be set aside late in development, leading to the expectation that plants accumulate somatic mutations along growth. Therefore, several predictions were made on the fate of somatic mutations: mutations have generally low frequency in plant tissues; mutations at high frequency have a higher chance of intergenerational transmission; branching topology of the tree dictates mutation distribution; and exposure to UV (ultraviolet) radiation increases mutagenesis. To provide insights into mutation accumulation and transmission in plants, we produced two high-quality reference genomes and a unique dataset of 60 high-coverage whole-genome sequences of two tropical tree species, Dicorynia guianensis (Fabaceae) and Sextonia rubra (Lauraceae). We identified 15,066 de novo somatic mutations in D. guianensis and 3,208 in S. rubra, surprisingly almost all found at low frequency. We demonstrate that 1) low-frequency mutations can be transmitted to the next generation; 2) mutation phylogenies deviate from the branching topology of the tree; and 3) mutation rates and mutation spectra are not demonstrably affected by differences in UV exposure. Altogether, our results suggest far more complex links between plant growth, aging, UV exposure, and mutation rates than commonly thought.

Mots-clés Agrovoc : phylogénie, mutation, génie génétique, mutation somatique, génome, variation génétique, génomique

Mots-clés géographiques Agrovoc : Guyane française, France

Mots-clés complémentaires : Dicorynia guianensis, Sextonia rubra

Classification Agris : F30 - Génétique et amélioration des plantes
K01 - Foresterie - Considérations générales

Champ stratégique Cirad : CTS 1 (2019-) - Biodiversité

Auteurs et affiliations

• Schmitt Sylvain, CIRAD-ES-UPR Forêts et sociétés (FRA) ORCID: 0000-0001-7759-7106 - auteur correspondant
• Heuret Patrick, INRAE (FRA)
• Troispoux Valérie, INRAE (GUF)
• Beraud Mélmanie, Université Paris-Saclay (FRA)
• Cazal Jocelyn, INRAE (GUF)
• Chancerel Emilie, INRAE (FRA)
• Cravero Charlotte, INRAE (FRA)
• Guichoux Erwan, INRAE (FRA)
• Lepais Olivier, INRAE (FRA)
• Loureiro João, University of Coimbra (PRT)
• Marande William, INRAE (FRA)
• Martin-Ducup Olivier, INRAE (FRA)
• Vincent Grégoire, IRD (FRA)
• Chave Jérôme, CNRS (FRA)
• Plomion Christophe, INRAE (FRA)
• Leroy Thibault, INRAE (FRA)
• Heuertz Myriam, Université de Bordeaux (FRA)
• Tysklind Niklas, INRAE (FRA)

Source : Cirad-Agritrop (https://agritrop.cirad.fr/609897/)

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