Comparative evolutionary analyses of peste des petits ruminants virus genetic lineages

Courcelle Maxime, Salami Habib, Tounkara Kalidia, Lo Modou Moustapha, Ba Aminata, Diop Mariame, Niang Mamadou, Sidibé Cheick Abou Kounta, Sery Amadou, Dakouo Marthin, Kaba Lanceï, Sidime Youssouf, Keyra Mohamed, Diallo Alpha Oumar Sily, El Mamy Ahmed Bezeid, El Arbi Ahmed Salem, Barry Yahya, Isselmou Ekaterina, Habiboullah Habiboullah, Doumbia Baba, Gueya Mohamed Baba, Awuni Joseph Adongo, Odoom Theophilus, Ababio Patrick Tetteh, TawiahYingar Daniel Nana Yaw, Coste Caroline, Guendouz Samia, Kwiatek Olivier, Libeau Geneviève, Bataille Arnaud. 2024. Comparative evolutionary analyses of peste des petits ruminants virus genetic lineages. Virus Evolution, 10 (1):veae012, 15 p.

Url - jeu de données - Entrepôt autre : https://www.ncbi.nlm.nih.gov/bioproject/PRJNA717034/ / Url - jeu de données - Entrepôt autre : https://www.ncbi.nlm.nih.gov/nuccore/OR286474.1/ / Url - jeu de données - Entrepôt autre : https://www.ncbi.nlm.nih.gov/nuccore/OR286505

Résumé : Peste des petits ruminants virus (PPRV) causes a highly infectious disease affecting mainly goats and sheep in large parts of Africa, Asia, and the Middle East and has an important impact on the global economy and food security. Full genome sequencing of PPRV strains has proved to be critical to increasing our understanding of PPR epidemiology and to inform the ongoing global efforts for its eradication. However, the number of full PPRV genomes published is still limited and with a heavy bias towards recent samples and genetic Lineage IV (LIV), which is only one of the four existing PPRV lineages. Here, we generated genome sequences for twenty-five recent (2010–6) and seven historical (1972–99) PPRV samples, focusing mainly on Lineage II (LII) in West Africa. This provided the first opportunity to compare the evolutionary pressures and history between the globally dominant PPRV genetic LIV and LII, which is endemic in West Africa. Phylogenomic analysis showed that the relationship between PPRV LII strains was complex and supported the extensive transboundary circulation of the virus within West Africa. In contrast, LIV sequences were clearly separated per region, with strains from West and Central Africa branched as a sister clade to all other LIV sequences, suggesting that this lineage also has an African origin. Estimates of the time to the most recent common ancestor place the divergence of modern LII and LIV strains in the 1960s–80s, suggesting that this period was particularly important for the diversification and spread of PPRV globally. Phylogenetic relationships among historical samples from LI, LII, and LIII and with more recent samples point towards a high genetic diversity for all these lineages in Africa until the 1970s–80s and possible bottleneck events shaping PPRV's evolution during this period. Molecular evolution analyses show that strains belonging to LII and LIV have evolved under different selection pressures. Differences in codon usage and adaptative selection pressures were observed in all viral genes between the two lineages. Our results confirm that comparative genomic analyses can provide new insights into PPRV's evolutionary history and molecular epidemiology. However, PPRV genome sequencing efforts must be ramped up to increase the resolution of such studies for their use in the development of efficient PPR control and surveillance strategies.

Mots-clés Agrovoc : peste des petits ruminants, virus peste petits ruminants, phylogénie, épidémiologie, génie génétique, surveillance épidémiologique, évolution, génome, contrôle de maladies, séquence nucléotidique, maladie des animaux

Mots-clés géographiques Agrovoc : Burkina Faso, Ghana, Inde, Soudan, Sénégal

Mots-clés libres : Morbillivirus, Phylogenetics, Evolution, Small ruminants, Épizootic, Endemic

Classification Agris : L73 - Maladies des animaux
L10 - Génétique et amélioration des animaux

Champ stratégique Cirad : CTS 4 (2019-) - Santé des plantes, des animaux et des écosystèmes

Agences de financement européennes : European Commission

Projets sur financement : (EU) ANIHWA CALL1:Improved Understanding of Epidemiology of PPR

Auteurs et affiliations

• Courcelle Maxime, CIRAD-BIOS-UMR ASTRE (FRA)
• Salami Habib, LNERV (SEN)
• Tounkara Kalidia, LCV (MLI)
• Lo Modou Moustapha, LNERV (SEN)
• Ba Aminata, LNERV (SEN)
• Diop Mariame, LNERV (SEN)
• Niang Mamadou, LCV (MLI)
• Sidibé Cheick Abou Kounta, LCV (MLI)
• Sery Amadou, LCV (MLI)
• Dakouo Marthin, LCV (MLI)
• Kaba Lanceï, Institut Supérieur des Sciences et de Médecine Vétérinaire (GIN)
• Sidime Youssouf, Institut Supérieur des Sciences et de Médecine Vétérinaire (GIN)
• Keyra Mohamed, Institut Supérieur des Sciences et de Médecine Vétérinaire (GIN)
• Diallo Alpha Oumar Sily, Institut Supérieur des Sciences et de Médecine Vétérinaire (GIN)
• El Mamy Ahmed Bezeid, ONARDEL (MRT)
• El Arbi Ahmed Salem, ONARDEL (MRT)
• Barry Yahya, ONARDEP (MRT)
• Isselmou Ekaterina, ONARDEL (MRT)
• Habiboullah Habiboullah, ONARDEL (MRT)
• Doumbia Baba, ONARDEL (MRT)
• Gueya Mohamed Baba, ONARDEL (MRT)
• Awuni Joseph Adongo, Accra Veterinary Laboratory (GHA)
• Odoom Theophilus, Accra Veterinary Laboratory (GHA)
• Ababio Patrick Tetteh, Accra Veterinary Laboratory (GHA)
• TawiahYingar Daniel Nana Yaw, Accra Veterinary Laboratory (GHA)
• Coste Caroline, CIRAD-BIOS-UMR ASTRE (FRA)
• Guendouz Samia, CIRAD-BIOS-UMR ASTRE (FRA)
• Kwiatek Olivier, CIRAD-BIOS-UMR ASTRE (FRA)
• Libeau Geneviève, CIRAD-BIOS-UMR ASTRE (FRA)
• Bataille Arnaud, CIRAD-BIOS-UMR ASTRE (FRA) ORCID: 0000-0002-3508-2144 - auteur correspondant

Source : Cirad-Agritrop (https://agritrop.cirad.fr/611940/)

Métriques

[ Page générée et mise en cache le 2025-03-09 ]