Characterization, anti-oxidative and anti-inflammatory effects of Costa Rican noni juice (Morinda citrifolia L.)

Dussossoy Emilie, Brat Pierre, Bony Emilie, Boudard Frédéric, Poucheret Patrick, Mertz Christian, Giaimis Jean, Michel Alain. 2011. Characterization, anti-oxidative and anti-inflammatory effects of Costa Rican noni juice (Morinda citrifolia L.). Journal of Ethnopharmacology, 133 (1) : 108-115.

https://doi.org/10.1016/j.jep.2010.08.063

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Quartile : Q1, Sujet : PLANT SCIENCES / Quartile : Q1, Sujet : INTEGRATIVE & COMPLEMENTARY MEDICINE / Quartile : Q2, Sujet : PHARMACOLOGY & PHARMACY / Quartile : Q2, Sujet : CHEMISTRY, MEDICINAL

Liste HCERES des revues (en SHS) : oui

Thème(s) HCERES des revues (en SHS) : Psychologie-éthologie-ergonomie

Résumé : Aim of the study: Noni fruit (Morinda citrifolia L.) juice has been used for more than 2000 years in Polynesia as a traditional folk medicine. The aim of the present study was to finely characterize noni juice from Costa Rica and to evaluate its anti-oxidative and anti-inflammatory activities. Materials and methods: A microfiltrated noni juice was prepared with Costarican nonis. HPLC-DAD and Electro Spray Ionization Mass Spectrometric detection (HPLC-ESI-MS) were used to identify phenolic compounds and iridoids. The anti-oxidative activity of noni juice was measured in vitro by both Oxygen Radical Absorbance Capacity (ORAC) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging methods. The anti-inflammatory effects of noni juice were investigated in vitro by: measuring its effect on nitric oxide and prostaglandin E2 production by activated macrophages, evaluating its inhibitory activities on cyclooxygenase (COX)-1 and -2 and in vivo on a carrageenan-induced paw oedema model in rats. Results: Several polyphenols belonging to the coumarin, flavonoid and phenolic acid groups, and two iridoids were identified. Noni juice demonstrated a mean range free radical scavenging capacity. Furthermore, it also reduced carrageenan-induced paw oedema, directly inhibited cyclooxygenase COX-1 and COX-2 activities and inhibited the production of nitric oxide (NO) and prostaglandins E2 (PGE2) in activated J774 cells, in a dose dependent manner. Conclusions: This study showed that noni's biological effects include: (1) anti-oxidant properties probably associated with phenolic compounds, iridoids and ascorbic acid and (2) anti-inflammatory action through NO and PGE2 pathways that might also be strengthened by anti-oxidant effects.

Mots-clés Agrovoc : jus de fruits, Rubiaceae, anti-inflammatoire, composé phénolique, antioxydant, Morinda citrifolia

Mots-clés géographiques Agrovoc : Costa Rica

Classification Agris : Q04 - Composition des produits alimentaires
000 - Autres thèmes

Champ stratégique Cirad : Axe 3 (2005-2013) - Alimentation accessible et de qualité

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