How to boost antioxidants by lipophilization?

Laguerre Mickaël, Bayrasy Christelle, Lecomte Jérôme, Chabi Béatrice, Decker Eric Andrew, Wrutniak-Cabello Chantal, Cabello Gérard, Villeneuve Pierre. 2013. How to boost antioxidants by lipophilization?. Biochimie, 95 (1) : 20-26.

https://doi.org/10.1016/j.biochi.2012.07.018

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Quartile : Q2, Sujet : BIOCHEMISTRY & MOLECULAR BIOLOGY

Résumé : Covalent modification of antioxidants through lipophilization is an important field of research aiming at developing antioxidants with improved efficacy. However, due to insufficient knowledge on how hydrophobicity affects antioxidant activity, lipophilization strategies have been largely based on empirism. Often, the resulting lipophilized antioxidants were not optimal. Here we described how the body of knowledge regarding hydrophobicity has been dramatically redefined as unexpected results were recently published. Using a broad range of lipophilized antioxidants assessed in dispersed lipids models and cultured cells, it has been demonstrated that the antioxidant activity increases progressively with increasing chain length up to a critical point, beyond which the activity of the compounds dramatically decreases. Taking into account this nonlinear phenomenon, also known as cut-off effect, antioxidant drug designers now have to seek the critical chain length to synthesize the optimal drug in a rational manner. Here, we briefly presented three putative mechanisms of action to try to account for the cut-off effect.

Mots-clés Agrovoc : antioxydant, réaction chimique, hydrophobicité, acide gras, composé phénolique, estérification

Mots-clés complémentaires : Lipophilisation

Classification Agris : Q02 - Traitement et conservation des produits alimentaires
000 - Autres thèmes

Champ stratégique Cirad : Hors axes (2005-2013)

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